RNA interference (RNAi) provides researchers with a versatile means to modulate target
gene expression. The major forms of RNAi molecules, genome-derived microRNAs …

The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Transfection is a modern and powerful method used to insert foreign nucleic acids into
eukaryotic cells. The ability to modify host cells' genetic content enables the broad …

Targeted delivery to the diseased cell or tissue is the key to the successful clinical use of
nucleic acid drugs. In particular, delivery of microRNA-140 (miRNA-140, miR-140) into …

Breast cancer (BC) is the most common cancer in women and poses a serious threat to their
health. Despite familiarity with factors affecting its etiology, initiation, progression, treatment …

MicroRNAs (miRNAs) represent a family of short non-coding regulatory RNA molecules that
are produced in a tissue and time-specific manner to orchestrate gene expression post …

Simple Summary Cancer is a complex disease associated with deregulation of numerous
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …

Mesenchymal stem cells (MSCs) are known as promising sources for cancer therapy and
can be utilized as vehicles in cancer gene therapy. MSC-derived exosomes are central …

ABSTRACT Introduction The novel coronavirus (CoV) disease 2019 (COVID-19) is a viral
infection that causes severe acute respiratory syndrome (SARS). It is believed that early …

Background Researchers now have a new avenue to investigate when it comes to miRNA-
based therapeutics. miRNAs have the potential to be valuable biomarkers for disease …