Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term
loss of kidney function. The progression of CKD has repercussions for other organs, leading …

α-Klotho is highly expressed in the kidney, and its extracellular domain is cleaved and
released into the circulation. Chronic kidney disease (CKD) is a state of α-Klotho deficiency …

Reducing oxidative stress stands at the center of a prevention and control strategy for
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …

Cardiac hypertrophy occurs in up to 95% of patients with CKD and increases their risk for
cardiovascular death. In the kidney, full-length membranous Klotho forms the coreceptor for …

It is commonly held that osteitis fibrosa and mixed uremic osteodystrophy are the
predominant forms of renal osteodystrophy in patients with chronic kidney disease. Osteitis …

The patient with chronic kidney disease (CKD) represents an extreme model for
arteriosclerosis, vascular calcification, and bone disorders, all of which are also associated …

OBJECTIVE The glycemic management of patients with type 2 diabetes mellitus (T2DM) and
renal impairment is challenging, with few treatment options. We investigated the effect of …

AKI confers increased risk of progression to CKD. αKlotho is a cytoprotective protein, the
expression of which is reduced in AKI, but the relationship of αKlotho expression level to AKI …

Background αKlotho is the prototypic member of the Klotho family and is most highly
expressed in the kidney. αKlotho has pleiotropic biologic effects, and in the kidney, its …