Chronic liver disease (CLD) is a continuous process that causes a reduction of liver function
lasting more than six months. CLD includes alcoholic liver disease (ALD), non-alcoholic fatty …

Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of approximately 25%
and is associated with high morbidity and high mortality. NAFLD is a leading cause of …

As a metabolic disruptor, bisphenol A (BPA) has been widely reported to disrupt lipid
balance. Moreover, BPA has gained significant attention due to its estrogenic activity. While …

Metabolic dysfunction-associated fatty liver disease (MAFLD) is frequently linked to type 2
diabetes mellitus (T2DM), and both conditions exacerbate the progression of the other …

The increase of tear osmolarity caused by excessive evaporation of tear phase is the main
pathological mechanism of dry eye disease (DED). Puerarin, the major bioactive ingredient …

Sirtuins, also called silent information regulator 2, are enzymes that rely on nicotinamide
adenine dinucleotide (NAD+) to function as histone deacetylases. Further investigation is …

Osteoporosis is a chronic progressive bone disease characterized by the decreased
osteogenic ability of osteoblasts coupled with increased osteoclast activity. Natural products …

Hepatic lipid accumulation promotes the development of non-alcoholic fatty liver disease
(NAFLD) in type 2 diabetes mellitus (T2DM). However, the underlying mechanism remains …

Alcoholic liver disease (ALD) has a multifaceted development, progressing from alcoholic
steatosis to alcoholic hepatitis and ultimately to alcoholic cirrhosis, irreversible liver damage …

Puerarin, a monomer of traditional Chinese medicine, is a key component of Pueraria radix.
Both clinical and experimental researches demonstrated that puerarin has therapeutic …