Biofabrication paradigms in corneal regeneration: bridging bioprinting techniques, natural bioinks, and stem cell therapeutics

P Pal, S Sambhakar, S Paliwal, S Kumar… - Journal of Biomaterials …, 2024 - Taylor & Francis
Corneal diseases are a major cause of vision loss worldwide. Traditional methods like
corneal transplants from donors are effective but face challenges like limited donor …

Replace or Regenerate? Diverse Approaches to Biomaterials for Treating Corneal Lesions

P Bonato, A Bagno - Biomimetics, 2024 - mdpi.com
The inner structures of the eye are protected by the cornea, which is a transparent
membrane exposed to the external environment and subjected to the risk of lesions and …

Design and Applications of Dynamic Hydrogels Based on Reversible C═ N Bonds

H Yang, CA Fustin - Macromolecular Chemistry and Physics, 2023 - Wiley Online Library
Dynamic hydrogels offer the opportunity to meet the expectations of smart materials with
adaptable properties such as stimuli responsiveness, self‐healing, shear thinning, stress …

Expansion and characterization of human limbus-derived stromal/mesenchymal stem cells in xeno-free medium for therapeutic applications

A Sahoo, M Damala, J Jaffet, D Prasad, S Basu… - Stem Cell Research & …, 2023 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have been proven to prevent and
clear corneal scarring and limbal stem cell deficiency. However, using animal-derived serum …

Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases

Y Liang, X Sun, C Duan, S Tang, J Chen - Stem Cell Research & Therapy, 2023 - Springer
Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration
and impose a considerable economic burden on patients and society, making efforts to cure …

Advancements of 3D bioprinting in regenerative medicine: Exploring cell sources for organ fabrication

Y Ma, B Deng, R He, P Huang - Heliyon, 2024 - cell.com
Abstract 3D bioprinting has unlocked new possibilities for generating complex and
functional tissues and organs. However, one of the greatest challenges lies in selecting the …

Bioprinting: Mechanical stabilization and reinforcement strategies in regenerative medicine

A Ballard, R Patush, J Perez, C Juarez… - … Engineering Part A, 2024 - liebertpub.com
Bioprinting describes the printing of biomaterials and cell-laden or cell-free hydrogels with
various combinations of embedded bioactive molecules. It encompasses the precise …

[HTML][HTML] Novel strategy for multi-material 3D bioprinting of human stem cell based corneal stroma with heterogenous design

P Puistola, S Miettinen, H Skottman, A Mörö - Materials Today Bio, 2024 - Elsevier
Abstract Three-dimensional (3D) bioprinting offers an automated, customizable solution to
manufacture highly detailed 3D tissue constructs and holds great promise for regenerative …

3D Bioprinting of Acellular Corneal Stromal Scaffolds with a Low Cost Modified 3D Printer: A Feasibility Study

AA Gingras, PA Jansen, C Smith, X Zhang… - Current Eye …, 2023 - Taylor & Francis
Purpose Loss of corneal transparency is one of the major causes of visual loss, generating a
considerable health and economic burden globally. Corneal transplantation is the leading …

Biologicals and Biomaterials for Corneal Regeneration and Vision Restoration in Limbal Stem Cell Deficiency

ND Girolamo - Advanced Materials, 2024 - Wiley Online Library
The mammalian cornea is decorated with stem cells bestowed with the life‐long task of
renewing the epithelium, provided they remain healthy, functional and in sufficient numbers …