Cell therapies are powerful technologies in which human cells are reprogrammed for
therapeutic applications such as killing cancer cells or replacing defective cells. The …

Conventional biological experiments often focus on in vitro assays because of the inherent
limitations when handling multiple variables in vivo, including labor-intensive and time …

The construction of synthetic gene circuits requires the rational combination of multiple
regulatory components, but predicting their behavior can be challenging due to poorly …

Highlights•Engineering for the bioproduction of natural products is bottlenecked by
screening.•To overcome this, we explore advancements in biosensors and analytical …

Here, we present a method for expressing multiple open reading frames (ORFs) from single
transcripts using the leaky scanning model of translation initiation. In this approach termed" …

Synthetic gene expression in engineered cells typically depends on the host cell's limited
pool of intracellular resources, which can lead to resource competition between native and …

Live-cell reporting of regulated transcription factor (TF) activity has a wide variety of
applications in synthetic biology, drug discovery, and functional genomics. As a result, there …

Gene expression is a critical component of brain physiology and activity, but monitoring this
expression in the living brain represents a significant challenge. Here, we introduce a new …

Live-cell reporting of regulated transcription factor (TF) activity has a wide variety of
applications in synthetic biology, drug discovery, and functional genomics. As a result, there …