Novel Quinazolinone Derivatives: Potential Synthetic Analogs for the Treatment of Glaucoma, Alzheimer's Disease and Diabetes Mellitus
Quinazolinones, which represent an important part of nitrogen‐containing six‐membered
heterocyclic compounds, are frequently used in drug design due to their wide biological …
heterocyclic compounds, are frequently used in drug design due to their wide biological …
Synthesis and Evaluation of Quinazolin‐4(3H)‐one Derivatives as Multitarget Metabolic Enzyme Inhibitors: A Biochemistry‐Oriented Drug Design
In this study, imines bearing quinazolin‐4 (3H)‐one were synthesized and their inhibitory
properties were investigated against some metabolic enzymes including …
properties were investigated against some metabolic enzymes including …
Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: bioactivity, cytotoxicity, and molecular modeling studies
Despite significant developments in therapeutic strategies, Diabetes Mellitus remains an
increasing concern, leading to various complications, eg, cataracts, neuropathy, retinopathy …
increasing concern, leading to various complications, eg, cataracts, neuropathy, retinopathy …
Autophagy, Pyroptosis and Ferroptosis are Rising Stars in the Pathogenesis of Diabetic Nephropathy
X Li, L Gao, X Li, J Xia, Y Pan, C Bai - … , Metabolic Syndrome and …, 2024 - Taylor & Francis
Diabetic nephropathy (DN) is one of the most common microvascular complications in
diabetes and can potentially develop into end-stage renal disease. Its pathogenesis is …
diabetes and can potentially develop into end-stage renal disease. Its pathogenesis is …
Synthesis, characterization and molecular docking studies of highly selective new hydrazone derivatives of anthranilic acid and their ring closure analogue Quinazolin …
In this study, new Schiff bases derived from anthranilic acid hydrazide (3a-j) and quinazolin-
4 (3H)-one (4a-j) were synthesized with high yields (99-90%) and characterized by FTIR …
4 (3H)-one (4a-j) were synthesized with high yields (99-90%) and characterized by FTIR …
New Anthranilic Acid Hydrazones as Fenamate Isosteres: Synthesis, Characterization, Molecular Docking, Dynamics & in Silico ADME, in Vitro Anti‐Inflammatory …
H Şenol, Z Çağman… - Chemistry & …, 2023 - Wiley Online Library
In this study, twenty new anthranilic acid hydrazones 6–9 (a–e) were synthesized and their
structures were characterized by Fourier‐transform Infrared (FT‐IR), Nuclear Magnetic …
structures were characterized by Fourier‐transform Infrared (FT‐IR), Nuclear Magnetic …
Novel quinazoline–chromene hybrids as anticancer agents: Synthesis, biological activity, molecular docking, dynamics and ADME studies
In this study, new quinazoline–chromene hybrid compounds were synthesized. The
cytotoxic effects on cell viability of the hybrid compounds were tested against A549 human …
cytotoxic effects on cell viability of the hybrid compounds were tested against A549 human …
Selectivity Challenges for Aldose Reductase Inhibitors: A Review on Comparative SAR and Interaction Studies
P Kumari, R Kohal, GD Gupta, SK Verma - Journal of Molecular Structure, 2024 - Elsevier
Chronic hyperglycemia initiates multiple pathways that contribute to developing
complications in individuals with diabetes, ultimately leading to significant health problems …
complications in individuals with diabetes, ultimately leading to significant health problems …
Screening of in Vitro Inhibition of Lactoperoxidase Enzyme by Methyl Benzoate Derivatives with Molecular Docking Studies
Lactoperoxidase enzyme (LPO) is secreted from salivary, mammary, and other mucosal
glands including the bronchi, lungs, and nose, which had functions as a natural and the first …
glands including the bronchi, lungs, and nose, which had functions as a natural and the first …
Torachrysone-8-O-β-d-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products
W Zhao, D Xu, J Wang - Biochemical Pharmacology, 2023 - Elsevier
Aldose reductase (AR) is an important enzyme involved in the reduction of various aldehyde
and carbonyl compounds, including the highly reactive and toxic 4-hydroxynonenal (4 …
and carbonyl compounds, including the highly reactive and toxic 4-hydroxynonenal (4 …