Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The
acute efficacy of ketamine in TRD has been demonstrated in replicated randomised …

Repurposing ketamine in the therapy of depression could well represent a breakthrough in
understanding the etiology of depression. Ketamine was originally used as an anesthetic …

Currently, only a limited number of interventions can rapidly relieve depressive
symptomatology in patients with major depressive disorder or bipolar disorder experiencing …

Purpose To evaluate the relationship of sleep disturbance to the antidepressant effects of
esketamine. Materials and Methods Two double-blind, 4-week studies randomized adults …

Background Pain strongly coexists with depression. Ketamine has great analgesic and
antidepressant effects, acting as a promising role in treating depression with pain. Few …

Cerca de um terço das pessoas acometidas com depressão não respondem aos
tratamentos até então conhecidos e aprovados. Estudos demonstraram que a cetamina, um …