The safe, highly effective measles vaccine has been recommended globally since 1974, yet
in 2017 there were more than 17 million cases of measles and 83,400 deaths in children …

Developing precise and efficient gene editing approaches using CRISPR in primary human
T cell subsets would provide an effective tool in decoding their functions. Toward this goal …

Tie2-promoter-mediated loss of peroxisome proliferator-activated receptor gamma (PPARγ,
also known as PPARG) in mice leads to osteopetrosis and pulmonary arterial hypertension …

Background There are a number of studies regarding to the susceptibility of A20 SNPs in
rheumatoid arthritis (RA); however, a few of these studies have shown an association …

Abstract Hepatitis B virus X (HBx) protein contributes to the progression of hepatitis B virus
(HBV)-related hepatic injury and diseases, but the exact mechanism remains unclear …

The fishing cat (Prionailurus viverrinus) is a vulnerable wild felid that is currently under threat
from habitat destruction and other human activities. The zoo provides insurance to ensure …

Despite the success of imatinib and other tyrosine kinase inhibitors (TKIs), chronic myeloid
leukemia (CML) remains largely incurable, and a number of CML patients die due to Abl …

Background Knowledge of the oncogenic signaling pathways of T-cell acute lymphoblastic
leukemia (T-ALL) remains limited. Constitutive aberrant activation of the nuclear factor …

A20 is a repressor of NF-κB and was recently shown to be frequently inactivated by
deletions or mutations in several types of lymphomas including T-cell lymphoma. Little is …

Despite significant improvement in our understanding of t-cell acute lymphoblastic leukemia
(T-ALL) biology and pathogenesis, many questions remain unanswered. In previous studies …