Gene therapy has emerged as a promising therapeutic strategy for various conditions,
including blood disorders, ocular disease, cancer, and nervous system disorders. The …

Neurodegenerative diseases are critical in the healthcare system as patients suffer from
progressive diseases despite currently available drug management. Indeed, the growing …

This study evaluated the synthesis of a dual series of bromo (CHB1–CHB4)-and fluoro
(CHF1–CHF4)-based α, β-unsaturated ketones and their inhibitory activities against …

Dysregulation of the interleukin-1 (IL-1) pathway leads to immune diseases that can result in
chronic tissue and organ inflammation. Although IL-1 blockade has shown promise in …

The use of biomaterials in delivering CRISPR/Cas9 for gene therapy in infectious diseases
holds tremendous potential. This innovative approach combines the advantages of …

Various chemical modifications of all RNA transcripts, or epitranscriptomics, have emerged
as crucial regulators of RNA metabolism, attracting significant interest from both basic and …

Nucleic acid therapeutics have emerged as one of the very advanced and efficacious
treatment approaches for debilitating health conditions, including those diseases affecting …

Neurological diseases represent a prevalent and severe category of diseases, affecting
staggering 6.8 million individuals worldwide annually. These encompass …

Neurons and their connecting axons gradually degenerate in neurodegenerative diseases
(NDs), leading to dysfunctionality of the neuronal cells and eventually their death. Drug …

Topiramate (TPM) is widely used as monotherapy or add-on therapy in adults and children
(aged 2 to 16 years) with primary generalized tonic-clonic seizures or focal-onset seizures …