American Society of Hematology 2020 guidelines for sickle cell disease: prevention, diagnosis, and treatment of cerebrovascular disease in children and adults
Background: Central nervous system (CNS) complications are among the most common,
devastating sequelae of sickle cell disease (SCD) occurring throughout the lifespan …
devastating sequelae of sickle cell disease (SCD) occurring throughout the lifespan …
Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on …
Purpose—The purpose of this statement is to review the literature on childhood stroke and to
provide recommendations for optimal diagnosis and treatment. This statement is intended …
provide recommendations for optimal diagnosis and treatment. This statement is intended …
Central nervous system complications and management in sickle cell disease
MR DeBaun, FJ Kirkham - Blood, The Journal of the American …, 2016 - ashpublications.org
With advances in brain imaging and completion of randomized clinical trials (RCTs) for
primary and secondary stroke prevention, the natural history of central nervous system …
primary and secondary stroke prevention, the natural history of central nervous system …
Stroke with transfusions changing to hydroxyurea (SWiTCH)
RE Ware, RW Helms - Blood, The Journal of the American …, 2012 - ashpublications.org
Stroke is a devastating complication of sickle cell anemia (SCA) with high recurrence if
untreated. Chronic transfusions reduce recurrent strokes but have associated morbidities …
untreated. Chronic transfusions reduce recurrent strokes but have associated morbidities …
Antithrombotic therapy in neonates and children: American College of Chest Physicians evidence-based clinical practice guidelines
This chapter about antithrombotic therapy in neonates and children is part of the
Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence …
Antithrombotic and Thrombolytic Therapy: American College of Chest Physicians Evidence …
Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years
S Chaturvedi, MR DeBaun - American journal of hematology, 2016 - Wiley Online Library
Over the past 40 years, public health measures such as universal newborn screening,
penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive …
penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive …
The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy
RP Hebbel, R Osarogiagbon, D Kaul - Microcirculation, 2004 - Taylor & Francis
A single amino acid substitution in hemoglobin comprises the molecular basis for sickle cell
anemia, but evolution of the corresponding clinical disease is extraordinarily complicated …
anemia, but evolution of the corresponding clinical disease is extraordinarily complicated …
Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches
MH Steinberg - The Scientific World Journal, 2008 - Wiley Online Library
The root cause of sickle cell disease is a single β‐globin gene mutation coding for the sickle
β‐hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated …
β‐hemoglobin chain. Sickle hemoglobin tetramers polymerize when deoxygenated …
[HTML][HTML] Epidemiology of stroke in sickle cell disease
FJ Kirkham, IA Lagunju - Journal of Clinical Medicine, 2021 - mdpi.com
Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …
haemorrhagic, and it also affects adults with the condition. Without any screening or …
[HTML][HTML] Haploidentical bone marrow transplantation with post-transplantation cyclophosphamide plus thiotepa improves donor engraftment in patients with sickle cell …
J de la Fuente, N Dhedin, T Koyama… - Biology of Blood and …, 2019 - Elsevier
Curative therapy for individuals with severe sickle cell disease (SCD) who lack an HLA-
identical sibling donor has been frustratingly elusive. In with the goal of improving …
identical sibling donor has been frustratingly elusive. In with the goal of improving …