The past two decades have seen a renewed interest and focus in pediatric stroke. Although
pediatric stroke in its various guises (acute infantile hemiplegia, hemiplegic cerebral palsy …

Red blood cell (RBC) transfusion is an essential treatment of sickle cell disease (SCD), with
more than 50% of affected children receiving at least 1 transfusion. 1 RBC transfusion …

Cerebrovascular abnormalities are a common feature of sickle cell disease that may be
associated with risk of vaso-occlusive pain crises, microinfarcts, and cognitive impairment …

BACKGROUND Chronic exchange transfusion is effective for primary and secondary
prevention of stroke in children with sickle cell anemia (SCA). Erythrocytapheresis is …

Background Patients with sickle cell disease (SCD) have just one recognized curative
therapy option: hematopoietic stem cell transplantation (HSCT), which results in a long …

Complications involving the central nervous system are among the most devastating
manifestations of sickle cell disease. Although overt stroke occurs in 1 in 10 children with …

A retrospective study was conducted to assess changes in cerebrovascular lesions, as
assessed by magnetic resonance (MR) imaging and angiography in 18 children with sickle …

Curative therapies for sickle cell disease include allogeneic hematopoietic stem cell
transplantation (HSCT) and gene-modified autologous stem cell transplantation. HSCT has …

Overt strokes, previously one of the most common neurological complications in sickle cell
disease (SCD), have become far less frequent with routine transcranial Doppler (TCD) …

Objectives: In children with sickle cell disease (SCD), chronic transfusion to maintain
haemoglobin S (HbS) below 30% markedly decreases both the risk of a first stroke when …