PURPOSE OF REVIEW This article presents an up-to-date summary of the genetic etiology,
diagnostic criteria, clinical features, and current management recommendations for the most …

Sickle cell disease (SCD) is a life-threatening genetic condition. Patients suffer from chronic
systemic and cerebral vascular disease that leads to early and cumulative neurological …

Sickle cell disease induces specific brain alterations that involve both the macrocirculation
and the microcirculation. The main overt neurovascular complications in children are …

Research consistently indicates that children with sickle cell disease (SCD) face multiple risk
factors for neurocognitive impairment. Despite this, no empirical research to date has …

Summary 'Paradoxical'embolization via intracardiac or intrapulmonary right‐to‐left shunts
(RLS) is an established cause of stroke. Hypercoagulable states and increased right heart …

Sickle cell anemia (SCA)-associated cerebral vasculopathy and moyamoya is a unique
entity reflecting the abnormal interactions between sickled red blood cells (RBCs) and the …

Both adult and pediatric patients with sickle cell disease face a higher risk of stroke than the
general population. Given the different underlying pathophysiology predisposing these …

Cerebrovascular abnormalities are a common feature of sickle cell disease that may be
associated with risk of vaso-occlusive pain crises, microinfarcts, and cognitive impairment …

Chronic transfusion therapy is the treatment of choice for preventing stroke recurrence in
children with sickle cell disease (SCD). The majority of children affected by this devastating …

Opinion statement Children with sickle disease are at high risk for ischemic stroke and
transient ischemic attacks, usually secondary to intracranial arteriopathy involving the …