Oocyte competence in women with polycystic ovary syndrome

S Palomba, J Daolio, GB La Sala - Trends in Endocrinology & Metabolism, 2017 - cell.com
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
reproductive age and affects fertility and pregnancy in cases of oligoanovulation. Ovulation …

[HTML][HTML] HYPOXIA AND REPRODUCTIVE HEALTH: Hypoxia and ovarian function: follicle development, ovulation, oocyte maturation

M Lim, JG Thompson, KR Dunning - Reproduction, 2021 - rep.bioscientifica.com
The ovarian follicle provides the oocyte with the ideal environment for growth and
development in preparation for ovulation and fertilisation. The follicle undergoes many …

[HTML][HTML] Epigenetic dynamics during preimplantation development

C Marcho, W Cui, J Mager - Reproduction, 2015 - rep.bioscientifica.com
In vitro maturation (IVM) offers significant benefits for human infertility treatment and animal
breeding, but this potential is yet to be fully realised due to reduced oocyte developmental …

Single-cell RNA sequencing analysis of mouse follicular somatic cells

S Li, LN Chen, HJ Zhu, X Feng, FY Xie… - Biology of …, 2021 - academic.oup.com
Within the development of ovarian follicle, in addition to cell proliferation and differentiation,
sophisticated cell–cell cross talks are established among follicular somatic cells such as …

[HTML][HTML] HIF1 driven transcriptional activity regulates steroidogenesis and proliferation of bovine granulosa cells

VS Baddela, A Sharma, M Michaelis, J Vanselow - Scientific reports, 2020 - nature.com
Abstract Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor, consisting
of a constitutively expressed β-subunit (HIF1B) and a regulated α-subunit (HIF1A). In the …

Bisphenol A and S impaired ovine granulosa cell steroidogenesis

O Téteau, M Jaubert, A Desmarchais… - …, 2020 - rep.bioscientifica.com
Bisphenols, plasticisers used in food containers, can transfer to food. Bisphenol A (BPA) has
been described as an endocrine disruptor and consequently banned from the food industry …

Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus–oocyte complexes

J Guo, L Shi, X Gong, M Jiang, Y Yin… - Journal of Cell …, 2016 - journals.biologists.com
Communication between oocytes and their companion somatic cells promotes the healthy
development of ovarian follicles, which is crucial for producing oocytes that can be fertilized …

Failure to launch: aberrant cumulus gene expression during oocyte in vitro maturation

HM Brown, KR Dunning, M Sutton-McDowall… - …, 2017 - rep.bioscientifica.com
In vitro maturation (ivM) offers significant benefits for human infertility treatment and animal
breeding, but this potential is yet to be fully realised due to reduced oocyte developmental …

Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance

S Imanaka, H Shigetomi, H Kobayashi - Reproductive Sciences, 2022 - Springer
The aim of this review is to summarize our current understanding of the molecular
mechanism for the glucose metabolism, especially pyruvate dehydrogenase (PDH), during …

Ovarian tissue damage after grafting: systematic review of strategies to improve follicle outcomes

L Cacciottola, J Donnez, MM Dolmans - Reproductive biomedicine online, 2021 - Elsevier
Frozen-thawed human ovarian tissue endures large-scale follicle loss in the early post-
grafting period, characterized by hypoxia lasting around 7 days. Tissue revascularization …