Cochleovestibular gene transfer in neonatal mice by canalostomy

JY Guo, YY Liu, TF Qu, Z Peng, J Xie, GP Wang… - …, 2017 - journals.lww.com
Impairments of the inner ear result in sensorineural hearing loss and vestibular dysfunction
in humans. A large proportion of these disorders are congenital, and involve both auditory …

Cellular origin and response of flat epithelium in the vestibular end organs of mice to Atoh1 overexpression

L He, JY Guo, TF Qu, W Wei, K Liu, Z Peng, GP Wang… - Hearing Research, 2020 - Elsevier
A flat epithelium (FE) may be found in the vestibular end organs of humans and mice with
vestibular dysfunction. However, the pathogenesis of FE is unclear and inducing hair cell …

Severe streptomycin ototoxicity in the mouse utricle leads to a flat epithelium but the peripheral neural degeneration is delayed

GP Wang, I Basu, LA Beyer, HT Wong, DL Swiderski… - Hearing research, 2017 - Elsevier
The damaged vestibular sensory epithelium of mammals has a limited capacity for
spontaneous hair cell regeneration, which largely depends on the transdifferentiation of …

AAV8-mediated Atoh1 overexpression induces dose-dependent regeneration of vestibular hair cells in adult mice

JY Guo, L He, ZR Chen, K Liu, SS Gong, GP Wang - Neuroscience letters, 2021 - Elsevier
Vestibular hair cells (HCs) are mechanoreceptors for the detection of head movement.
Vestibular HCs of adult mammals never completely regenerate after damage, resulting in …

Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle

A Cheng, T Wang, T Yang, G Pregernig, R McCarthy… - 2023 - researchsquare.com
Vestibular hair cells are mechanoreceptors critical for detecting head position and motion. In
mammals, hair cell loss causes vestibular dysfunction as spontaneous regeneration is …

[HTML][HTML] Research progress on flat epithelium of the inner ear

HE Lu, GUO Jing-Ying, LIU Ke, W Guo-Peng… - Physiological …, 2020 - ncbi.nlm.nih.gov
Sensorineural hearing loss and vertigo, resulting from lesions in the sensory epithelium of
the inner ear, have a high incidence worldwide. The sensory epithelium of the inner ear may …

关注前庭系统基础研究

刘博, 王国鹏 - 中国医学文摘(耳鼻咽喉科学), 2014 - cqvip.com
眩晕是一种临床常见症状, 研究表明前庭系统病变是导致眩晕的重要原因. 前庭毛细胞及其神经
支配损伤是很多患者罹患眩晕的基础原因, 充分的科学研究是解决临床问题的关键所在 …

哺乳动物前庭毛细胞损伤与再生的研究进展

郭婧滢, 王国鹏, 龚树生 - 中华耳鼻咽喉头颈外科杂志, 2017 - cqvip.com
眩晕是临床常见症状之一, 对患者的生活质量有明显影响. 前庭毛细胞损伤所引起的前庭功能
障碍是眩晕发生的重要原因, 目前尚无有效方法使损伤后的哺乳动物前庭毛细胞完全再生 …

[引用][C] 腺相关病毒Anc80L65 转染成年小鼠椭圆囊的实验研究

王国鹏, 贺璐, 郭婧滢, 陈钟壡, 龚树生 - 中华耳科学杂志, 2022

哺乳动物内耳扁平上皮的研究进展

贺璐, 龚树生, 王国鹏 - 中华耳科学杂志, 2019 - cqvip.com
感音神经性耳聋和前庭功能障碍是耳科临床的常见疾病, 对患者生活质量具有明显影响.
在部分重度听力损失和/或前庭功能障碍的组织标本中, 损伤的内耳感觉上皮会出现极度退化 …