Nutrition and autophagy deficiency in critical illness

I Vanhorebeek, M Casaer, J Gunst - Current Opinion in Critical …, 2023 - journals.lww.com
Insufficient autophagy during critical illness is at least partly explained by feeding-induced
suppression. This may explain why early enhanced nutrition failed to benefit critically ill …

The epigenetic legacy of ICU feeding and its consequences

I Vanhorebeek, G Van den Berghe - Current Opinion in Critical …, 2023 - journals.lww.com
Epigenetic abnormalities induced by critical illness or its nutritional management provide a
plausible molecular basis for their adverse effects on long-term outcomes. Identifying …

Our scientific journey through the ups and downs of blood glucose control in the ICU

G Van den Berghe, I Vanhorebeek… - American Journal of …, 2024 - atsjournals.org
This article tells the story of our long search for the answer to one question: Is stress
hyperglycemia in critically ill patients adaptive or maladaptive? Our earlier work had …

[HTML][HTML] Physical, emotional/behavioral, and neurocognitive developmental outcomes from 2 to 4 years after PICU admission: a secondary analysis of the early versus …

I Verlinden, F Güiza, K Dulfer… - Pediatric Critical Care …, 2022 - journals.lww.com
OBJECTIVES: PICU patients face long-term developmental impairments, partially
attributable to early parenteral nutrition (PN) versus late-PN. We investigated how this …

Timing of enteral nutrition and parenteral nutrition in the PICU

DM Fell, EA Bitetto, HE Skillman - Nutrition in Clinical Practice, 2023 - Wiley Online Library
The timing of nutrition support initiation has the potential to positively impact nutrition and
clinical outcomes in infants and children with critical illness. Early enteral nutrition within 24 …

[HTML][HTML] Neonatal frontal-limbic connectivity is associated with externalizing behaviours in toddlers with Congenital Heart Disease

AF Bonthrone, A Chew, MN Bhroin, FM Rech… - NeuroImage: Clinical, 2022 - Elsevier
Abstract Children with Congenital Heart Disease (CHD) are at increased risk of
neurodevelopmental impairments. The neonatal antecedents of impaired behavioural …

Impact of critical illness and withholding of early parenteral nutrition in the pediatric intensive care unit on long-term physical performance of children: a 4-year follow …

I Vanhorebeek, A Jacobs, L Mebis, K Dulfer… - Critical Care, 2022 - Springer
Background Many critically ill children face long-term developmental impairments. The
PEPaNIC trial attributed part of the problems at the level of neurocognitive and …

Novel insights in endocrine and metabolic pathways in sepsis and gaps for future research

A Téblick, J Gunst, L Langouche… - Clinical …, 2022 - portlandpress.com
Sepsis is defined as any life-threatening organ dysfunction caused by a dysregulated host
response to infection. It remains an important cause of critical illness and has considerable …

Ο επιγενετικός ρόλος της διατροφής στα παιδιά και τους εφήβους: Συστηματική ανασκόπηση

Μ Γκιουλέκα - 2023 - polynoe.lib.uniwa.gr
Εισαγωγή: Η διατροφή συνιστά πρωταρχικό καθοριστή της κατάστασης της υγείας των
πληθυσμών. Η Επιγενετική μελετά τις αιτιολογικές αλληλεπιδράσεις μεταξύ των γονιδίων και …