Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive
production or activation of osteoclasts leads to skeletal pathologies that affect a significant …

CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Lysosomes are essential catabolic organelles with an acidic lumen and dozens of hydrolytic
enzymes. The detrimental consequences of lysosomal leakage have been well known since …

In recent years, our vision of lysosomes has drastically changed. Formerly considered to be
mere degradative compartments, they are now recognized as key players in many cellular …

Lysosomes are organelles central to degradation and recycling processes in animal cells.
Whether lysosomal activity is coordinated to respond to cellular needs remains unclear. We …

The adult skeleton regenerates by temporary cellular structures that comprise teams of
juxtaposed osteoclasts and osteoblasts and replace periodically old bone with new. A …

Despite nearly two decades passing since the discovery of gene fusions involving TFE3 or
TFEB in sporadic renal cell carcinoma (RCC), the molecular mechanisms underlying the …

The dynamic nature of the skeleton is achieved by a process called “remodeling” which
involves the co-ordinated actions of osteoclasts, osteoblasts, osteocytes within the bone …

Perivascular epithelioid cell tumors, or PEComas, are mesenchymal neoplasms composed
of histologically and immunohistochemically distinctive epithelioid or spindle cells, which are …

Microphthalmia‐associated transcription factor (MITF) was initially shown to play a key role
in melanocyte differentiation through the direct transcriptional control of TYROSINASE …