Monoclonal antibody-based immunotherapy is now considered to be a main component of
cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies …

Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …

Human epidermal growth factor receptor 2 (HER2) is a well-known oncogenic driver in
different tumors and an approved therapeutic target in breast and gastroesophageal cancer …

Background Precision cancer medicine depends on defining distinct tumour subgroups
using biomarkers that may occur at very modest frequencies. One such subgroup comprises …

Highlights•The epidermal growth factor (EGFR) is a therapeutic option for patients with all
RAS WT metastatic colorectal cancer (mCRC).•A better knowledge of the mechanism of …

The clinical management of cancer has evolved in recent years towards more personalized
strategies that require a comprehensive knowledge of the complex molecular features …

Highlights•Monoclonal antibodies are effective treatment for various cancers and
autoimmune diseases.•Immune checkpoint therapy in cancer has emerged as a potent …

Although internal hernias are uncommon, they must be beared in mind in the differential
diagnosis in cases of intestinal obstruction, especially in patients with no history of previous …

Innate and acquired resistance to anti-EGFR therapy (EGFRi) is a major limitation in the
treatment of metastatic colorectal cancer (mCRC). Although RAS genes are the most …

Colorectal cancer (CRC), one of the leading causes of death among cancer patients, is a
heterogeneous disease and is characterized by diversions in multiple molecular pathways …