Neural Tube Defects in Embryos of Diabetic Mice: Role of the Pax-3 Gene and Apoptosis

SA Phelan, M Ito, MR Loeken - Diabetes, 1997 - Am Diabetes Assoc
Neural tube defects are among the most common of the malformations associated with
diabetic embryopathy. To study the molecular mechanisms by which neural tube defects …

Effects of diabetic pregnancy on the fetus and newborn

R Schwartz, KA Teramo - Seminars in perinatology, 2000 - Elsevier
Diabetes in pregnancy is unique because of the diversity of problems that can affect the
embryo/fetus beginning with conception. Considerable effort has been devoted to …

[HTML][HTML] Poor glycated haemoglobin control and adverse pregnancy outcomes in type 1 and type 2 diabetes mellitus: systematic review of observational studies

ME Inkster, TP Fahey, PT Donnan, GP Leese… - BMC pregnancy and …, 2006 - Springer
Background Glycaemic control in women with diabetes is critical to satisfactory pregnancy
outcome. A systematic review of two randomised trials concluded that there was no clear …

Recurrent pregnancy loss: evaluation and treatment

L Shahine, R Lathi - Obstetrics and Gynecology Clinics, 2015 - obgyn.theclinics.com
The definitions of miscarriage and recurrent pregnancy loss (RPL) are important to review
because they vary within the literature and clinical teaching. Classically, RPL is defined as 3 …

Oxidative and antioxidative status in pregnant women with either gestational or type 1 diabetes

E Peuchant, JL Brun, V Rigalleau, L Dubourg… - Clinical …, 2004 - Elsevier
Objectives: To evaluate oxidative and antioxidative status in pregnant diabetic women
between 26 and 32 weeks of gestation. Design and Methods: Free and total …

Maternal diabetes: an independent risk factor for major cardiovascular malformations with increased mortality of affected infants

CA Loffredo, PD Wilson, C Ferencz - Teratology, 2001 - Wiley Online Library
Background Intensive medical care of women with diabetes has reduced their risks of
bearing infants with congenital anomalies. To assess the preventive potential of …

Decreasing the burden of congenital heart anomalies: an epidemiologic evaluation of risk factors and survival

LD Botto, A Correa - Progress in Pediatric Cardiology, 2003 - Elsevier
The burden of congenital heart anomalies is ancient but not inevitable, and can be
decreased through primary prevention (removing causes) and improved survival. An …

[HTML][HTML] Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy

J Cederberg, CM Simán, UJ Eriksson - Pediatric research, 2001 - nature.com
The aim was to investigate whether dietary supplementation of a combination of the two
antioxidants, vitamin E and vitamin C, would protect the fetus in diabetic rat pregnancy at a …

Diabetes and embryonic malformations: role of substrate-induced free-oxygen radical production for dysmorphogenesis in cultured rat embryos

UJ Eriksson, LAHÅ Borg - Diabetes, 1993 - Am Diabetes Assoc
The aim of this study was to evaluate the role of free-oxygen radicals in the embryonic
maldevelopment of diabetic pregnancy. Rat embryos cultured in vitro during early …

Vitamin E decreases the occurrence of malformations in the offspring of diabetic rats

CM Simán, UJ Eriksson - Diabetes, 1997 - Am Diabetes Assoc
An association between excess oxygen radical activity and disturbed embryogenesis in
diabetic pregnancy has been suggested. In the present study, the protective capacity of …