Cancer stem cells (CSCs) are responsible for carcinogenesis and tumorigenesis and are
involved in drug and radiation resistance, metastasis, tumor relapse and initiation …

ABSTRACT Introduction Antimicrobial peptides (AMPs), also called host defense peptides
(HDPs), are identified in almost any form of life, which play an important role in innate …

Simple Summary Our study provided data that the inhibition of MEK/ERK signaling could
overcome Osimertinib resistance both in vitro and in vivo. Mechanistically, MEK inhibitor …

Poor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has
been driving the search for more active and specific compounds. In this work, we show how …

Extracellular vesicles (EVs) are nanosized particles released from most human cell types
that contain a variety of cargos responsible for mediating cell-to-cell and organ-to-organ …

There are few tumor cell subpopulations with stem cell characteristics in tumor tissue,
defined as cancer stem cells (CSCs) or cancer stem-like cells (CSLCs), which can …

Background: Patients with non-small cell lung cancer (NSCLC) initially responding to
tyrosine kinase inhibitors (TKIs) eventually develop resistance due to accumulating …

Objectives: Several studies demonstrated that aldehyde dehydrogenase (ALDH) and CD44
are the most considered cancer stem cells (CSC) markers. However, a comparison between …

Lung cancer is one of the most significant cancers as it accounts for almost 1 in 5 cancer
deaths worldwide, with an increasing incident rate. Management of the cancer has been …

Background: Cancers are one of the leading causes of deaths nowadays. The development
of new treatment schemes for oncological diseases is an interesting direction in …