IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation
W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …
system. They profoundly participate in immune responses during infection and inflammation …
Interleukin-22: immunobiology and pathology
JA Dudakov, AM Hanash… - Annual review of …, 2015 - annualreviews.org
Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …
Therapeutic opportunities of the IL-22–IL-22R1 system
R Sabat, W Ouyang, K Wolk - Nature reviews Drug discovery, 2014 - nature.com
Abstract Interleukin-22 (IL-22) is a key effector molecule that is produced by activated T cells,
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …
including T helper 22 (TH22) cells, TH17 cells and TH1 cells, as well as subsets of innate …
Regulation and functions of the IL-10 family of cytokines in inflammation and disease
The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …
The IL-20 subfamily of cytokines—from host defence to tissue homeostasis
Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …
IL‐22, not simply a Th17 cytokine
Summary Interleukin‐22 (IL‐22) has important functions in host defense at mucosal surfaces
as well as in tissue repair. It is unique as a cytokine that is produced by immune cells …
as well as in tissue repair. It is unique as a cytokine that is produced by immune cells …
[PDF][PDF] Interleukin‐22 treatment ameliorates alcoholic liver injury in a murine model of chronic‐binge ethanol feeding: role of signal transducer and activator of …
SH Ki, O Park, M Zheng, O Morales‐Ibanez… - …, 2010 - Wiley Online Library
Abstract Interleukin‐22 (IL‐22), a recently identified member of the IL‐10 family of cytokines
that is produced by Th17 and natural killer cells, plays an important role in controlling …
that is produced by Th17 and natural killer cells, plays an important role in controlling …
Recent advances in IL-22 biology
LA Zenewicz, RA Flavell - International immunology, 2011 - academic.oup.com
Several cell types, in particular epithelial cells, express the receptor for the cytokine IL-22
and upon its recognition produce molecules that are active both locally and systemically …
and upon its recognition produce molecules that are active both locally and systemically …
[HTML][HTML] Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is
activated by many cytokines and growth factors and plays a key role in cell survival …
activated by many cytokines and growth factors and plays a key role in cell survival …
[HTML][HTML] Alcoholic liver disease: A current molecular and clinical perspective
K Ohashi, M Pimienta, E Seki - Liver research, 2018 - Elsevier
Heavy alcohol use is the cause of alcoholic liver disease (ALD). The ALD spectrum ranges
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …
from alcoholic steatosis to steatohepatitis, fibrosis, and cirrhosis. In Western countries …