Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the
skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue …

Fibroblasts are the most common cell type of the connective tissues found throughout the
body and the principal source of the extensive extracellular matrix (ECM) characteristic of …

A diverse group of toxicants has been identified that cause injury to the lung including gases
(eg, ozone, chlorine), particulates/aerosols (eg, diesel exhaust, fly ash, other combustion …

Recruitment of immune cells to the site of inflammation by the chemokine CCL1 is important
in the pathology of inflammatory diseases. Here, we examined the role of CCL1 in …

Recent results call for the reexamination of the phenotype of wound macrophages and their
role in tissue repair. These results include the characterization of distinct circulating …

Pulmonary fibrosis and architectural remodeling of tissues can severely disrupt lung
function, often with fatal consequences. The etiology of pulmonary fibrotic diseases is varied …

Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Pulmonary fibrosis is the end stage of many diffuse parenchymal lung diseases. It is
characterised by excessive matrix formation leading to destruction of the normal lung …

Fibrosis is the production of excessive amounts of connective tissue, ie, scar formation, in
the course of reactive and reparative processes. Fibrosis develops as a consequence of …

Idiopathic pulmonary fibrosis (IPF) is one of a group of interstitial lung diseases that are
characterized by excessive matrix deposition and destruction of the normal lung …