Eotaxin-1/CCL11 and its receptor CCR3 are involved in recruitment of eosinophils to diverse
tissues, but their role in eosinophil recruitment in pulmonary fibrosis is unclear. The present …

Abstract Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, and often fatal form of
interstitial lung disease. It is characterized by injury with loss of lung epithelial cells and …

CCAAT/enhancer-binding proteins (C/EBPs) are a family of at least six identified
transcription factors that contain a highly conserved basic leucine zipper domain and …

Tenascin-C (TNC) is an extracellular matrix glycoprotein of unknown function that is highly
expressed in adult lung parenchyma following acute lung injury (ALI). Here we report that …

Rationale: Changes in peripheral blood cell populations have been observed but not
detailed at single-cell resolution in idiopathic pulmonary fibrosis (IPF). Objectives: To …

Scar and fibrosis are often the end result of mechanical injury and inflammatory diseases.
One chemokine that is repeatedly linked to fibrotic responses is monocyte chemoattractant …

Over the past decade, there has been a cohesive effort from patients, physicians, clinical
and basic scientists, and the pharmaceutical industry to find definitive treatments for …

Objective To investigate expression of the chemokine receptor CCR2 on key cell types
involved in the pathogenesis of systemic sclerosis (SSc) and to assess the potential for …

Pulmonary fibrosis is characterized by destruction and remodeling of the lung due to an
accumulation of collagen and other extracellular matrix components in the tissue. This …

Previous studies established that attenuating Wnt/β-catenin signaling limits lung fibrosis in
the bleomycin mouse model of this disease, but the contribution of this pathway to distinct …