Objective Previous studies have revealed the presence of IgG antifibroblast antibodies
(AFAs) capable of binding to the surface of fibroblasts in systemic sclerosis (SSc) sera. Since …

Apoptosis of lung structural cells is crucial in the process of normal tissue repair. Insufficient
apoptosis of lung fibroblasts may contribute to the development of fibrosis. Since the CC …

Advancements in cancer therapy increased the cancer free survival rates and reduced the
malignant related deaths. Therapeutic options for patients with thoracic cancers include …

Monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor (TGF)-β1 are
critical mediators of renal injury by promoting excessive inflammation and extracellular …

The potential for amniotic fluid stem cell (AFSC) treatment to inhibit the progression of fibrotic
lung injury has not been described. We have previously demonstrated that AFSC can …

Pulmonary fibrosis (PF) is a progressive interstitial inflammatory disease with a high
mortality rate. Patients with PF commonly experience a chronic dry cough and progressive …

CC chemokines play an important role in the pathogenesis of idiopathic pulmonary fibrosis.
Few studies have evaluated the efficacy of therapeutically targeting CC chemokines and …

ABSTRACT PI3Kγ is central in signaling diverse arrays of cellular functions and
inflammation. Pulmonary fibrosis is associated with pulmonary inflammation, angiogenesis …

In general, there are two types of animal models: natural and experimental. Because there
are no natural models for pulmonary fibrosis, an experimental model that reproduces key …

Chemokines coordinate lung inflammation and fibrosis by acting on chemokine receptors
expressed on leukocytes and other cell types. Atypical chemokine receptors (ACKRs) bind …