Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …

Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

The therapeutic potential of interleukin (IL)-2 in cancer treatment has been known for
decades, yet its widespread adoption in clinical practice remains limited. Recently, chimeric …

Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …

Long-term organ transplant survival remains suboptimal, and life-long immunosuppression
predisposes transplant recipients to an increased risk of infection, malignancy, and kidney …

Disorders in the regulatory arm of the adaptive immune system result in autoimmune‐
mediated diseases. While systemic immunosuppression is the prevailing approach to …

Simple Summary Adoptive immunotherapy has emerged as an effective alternative of
mounting impact to the current standard of care in cancer, viral infections, and recently …

The pleiotropic cytokine interleukin‐2 (IL‐2) is an integral regulator of healthy and
pathological immune responses, with the most important role in regulating the homeostasis …

IL2 signals pleiotropically on diverse cell types, some of which contribute to therapeutic
activity against tumors, whereas others drive undesired activity, such as immunosuppression …

Abstract The interleukin-2 (IL-2) cytokine plays a crucial role in regulating immune
responses and maintaining immune homeostasis. Its immunosuppressive effects have been …