[HTML][HTML] Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies
S Muhammad, T Fan, Y Hai, Y Gao, J He - Molecular Cancer, 2023 - Springer
Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …
responses. Their function and expression in the tumor microenvironment make them …
[HTML][HTML] The screening, identification, design and clinical application of tumor-specific neoantigens for TCR-T cells
J Li, Z Xiao, D Wang, L Jia, S Nie, X Zeng, W Hu - Molecular Cancer, 2023 - Springer
Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …
[HTML][HTML] IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy
V Niederlova, O Tsyklauri, M Kovar, O Stepanek - Trends in immunology, 2023 - cell.com
The therapeutic potential of interleukin (IL)-2 in cancer treatment has been known for
decades, yet its widespread adoption in clinical practice remains limited. Recently, chimeric …
decades, yet its widespread adoption in clinical practice remains limited. Recently, chimeric …
Eras of designer Tregs: Harnessing synthetic biology for immune suppression
K Tuomela, K Salim, MK Levings - Immunological Reviews, 2023 - Wiley Online Library
Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …
established as a critical cell type for regulating immune homeostasis through a plethora of …
[HTML][HTML] A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models
O Efe, RB Gassen, L Morena… - The Journal of …, 2024 - Am Soc Clin Investig
Long-term organ transplant survival remains suboptimal, and life-long immunosuppression
predisposes transplant recipients to an increased risk of infection, malignancy, and kidney …
predisposes transplant recipients to an increased risk of infection, malignancy, and kidney …
Microneedle‐mediated Delivery of Immunomodulators Restores Immune Privilege in Hair Follicles and Reverses Immune‐Mediated Alopecia
Disorders in the regulatory arm of the adaptive immune system result in autoimmune‐
mediated diseases. While systemic immunosuppression is the prevailing approach to …
mediated diseases. While systemic immunosuppression is the prevailing approach to …
[HTML][HTML] Promises and pitfalls of next-generation Treg adoptive immunotherapy
Simple Summary Adoptive immunotherapy has emerged as an effective alternative of
mounting impact to the current standard of care in cancer, viral infections, and recently …
mounting impact to the current standard of care in cancer, viral infections, and recently …
The soluble IL‐2 receptor α/CD25 as a modulator of IL‐2 function
The pleiotropic cytokine interleukin‐2 (IL‐2) is an integral regulator of healthy and
pathological immune responses, with the most important role in regulating the homeostasis …
pathological immune responses, with the most important role in regulating the homeostasis …
IL2 Targeted to CD8+ T Cells Promotes Robust Effector T-cell Responses and Potent Antitumor Immunity
KD Moynihan, MP Kumar, H Sultan, DC Pappas, T Park… - Cancer Discovery, 2024 - AACR
IL2 signals pleiotropically on diverse cell types, some of which contribute to therapeutic
activity against tumors, whereas others drive undesired activity, such as immunosuppression …
activity against tumors, whereas others drive undesired activity, such as immunosuppression …
Molecular engineering of Interleukin-2 for enhanced therapeutic activity in autoimmune diseases
LM Tomasovic, K Liu, D VanDyke, CS Fabilane… - Biodrugs, 2024 - Springer
Abstract The interleukin-2 (IL-2) cytokine plays a crucial role in regulating immune
responses and maintaining immune homeostasis. Its immunosuppressive effects have been …
responses and maintaining immune homeostasis. Its immunosuppressive effects have been …