The accurate joining of DNA double-strand breaks by homologous recombination repair
(HRR) is critical to the long-term survival of the cell. The three major mitogen-activated …

Cervical cancer is the second most common malignancy among women worldwide and is
highly radioresistant, often resulting in local treatment failure. For locally advanced disease …

Recent evidence indicates that limited availability and cytotoxicity have restricted the
development of natural killer (NK) cells in adoptive cellular immunotherapy (ACI). While it …

“Differentiation therapy” provides a unique and potentially effective, less toxic treatment
paradigm for cancer. Moreover, combining “differentiation therapy” with molecular …

The activity of human replication protein A (RPA) in DNA replication and repair is regulated
by phosphorylation of the middle RPA2 subunit. It has previously been shown that up to nine …

Radiotherapy is one of the major treatment regimes for thoracic malignancies, but can lead
to severe lung complications including pneumonitis and fibrosis. Recent studies suggest that …

Ionizing radiation (IR) is an ever-present hazard to humans primarily due to its mutagenic,
carcinogenic, and cell killing ability. In addition to causing DNA damage, irradiation initiates …

Radiation-induced liver disease (RILD), also known as radiation hepatitis, is a serious side
effect of radiotherapy (RT) for hepatocellular carcinoma. The therapeutic dose of RT can …

Prostaglandin E2 (PGE2) synthesis modulates the response to radiation injury in the mouse
intestinal epithelium through effects on crypt survival and apoptosis; however, the …

Radiation therapy (RT) is commonly used for the treatment of localized prostate cancer
(PCa). However, cancer cells often develop resistance to radiation through unknown …