Mycoplasma pneumoniae is an important cause of respiratory tract infections in children as
well as adults that can range in severity from mild to life-threatening. Over the past several …

Despite enormous progress in understanding the fundamentals of bacterial gene regulation,
our knowledge remains limited when compared with the number of bacterial genomes and …

Translation efficiency has been mainly studied by ribosome profiling, which only provides an
incomplete picture of translation kinetics. Here, we integrated the absolute quantifications of …

DNA-binding proteins are central regulators of chromosome organization; however, in
genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of …

DNA supercoiling acts as a global transcriptional regulator in bacteria, that plays an
important role in adapting their expression programme to environmental changes, but for …

Here, we determined the relative importance of different transcriptional mechanisms in the
genome-reduced bacterium Mycoplasma pneumoniae, by employing an array of …

Genome-wide measurements of transcriptional activity in bacteria indicate that the
transcription of successive genes is strongly correlated beyond the scale of operons. Here …

Gene context can have significant impact on gene expression but is currently not integrated
in quantitative models of gene regulation despite known biophysical principles and …

DNA supercoiling acts as a global and ancestral regulator of bacterial gene expression. In
this review, we advocate that it plays a pivotal role in host-pathogen interactions by …

Mycoplasmas have exceptionally streamlined genomes and are strongly adapted to their
many hosts, which provide them with essential nutrients. Owing to their relative genomic …