The energetic landscape of catch bonds in TCR interfaces
CM Ayres, SA Corcelli, BM Baker - The Journal of Immunology, 2023 - journals.aai.org
Recognition of peptide/MHC complexes by αβ TCRs has traditionally been viewed through
the lens of conventional receptor–ligand theory. Recent work, however, has shown that TCR …
the lens of conventional receptor–ligand theory. Recent work, however, has shown that TCR …
Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity
Antigen recognition by the T cell receptor (TCR) of CD4+ T cells can be greatly enhanced by
the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra …
the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra …
Explaining and predicting allostery with allosteric database and modern analytical techniques
J Zha, M Li, R Kong, S Lu, J Zhang - Journal of Molecular Biology, 2022 - Elsevier
Allostery is a phenomenon that the protein activity is regulated when a non-functional site on
it is bounded. This phenomenon is important in life process and disease therapy. However, it …
it is bounded. This phenomenon is important in life process and disease therapy. However, it …
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation
AL Lanz, G Masi, N Porciello, A Cohnen, D Cipria… - Cell reports, 2021 - cell.com
The mechanism of T cell antigen receptor (TCR-CD3) signaling remains elusive. Here, we
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide …
identify mutations in the transmembrane region of TCRβ or CD3ζ that augment peptide …
Evaluation of Molecular Simulations and Deep Learning Prediction of Antibodies' Recognition of TRBC1 and TRBC2
T cell receptor β-chain constant (TRBC) is a promising class of cancer targets consisting of
two highly homologous proteins, TRBC1 and TRBC2. Developing targeted antibody …
two highly homologous proteins, TRBC1 and TRBC2. Developing targeted antibody …
Widespread introgression of MHC genes in Iberian Podarcis lizards
TS Gaczorek, M Chechetkin, K Dudek… - Molecular …, 2023 - Wiley Online Library
Major histocompatibility complex (MHC) genes are crucial for the adaptive immune
response of jawed vertebrates. Their variation, reaching extreme levels, is driven mainly by …
response of jawed vertebrates. Their variation, reaching extreme levels, is driven mainly by …
Chitosan oligosaccharide improves the mucosal immunity of small intestine through activating SIgA production in mice: Proteomic analysis
J Wen, X Niu, S Chen, Z Chen, S Wu, X Wang… - International …, 2022 - Elsevier
Chitosan oligosaccharide (COS) plays a vital role in improving the host system and mucosal
immune function. So far, the impact of COS on mucosal immune response in the early stage …
immune function. So far, the impact of COS on mucosal immune response in the early stage …
Molecular dynamics simulations reveal membrane lipid interactions of the full-length lymphocyte specific kinase (Lck)
The membrane-bound lymphocyte-specific protein-tyrosine kinase (Lck) triggers T cell
antigen receptor signalling to initiate adaptive immune responses. Despite many structure …
antigen receptor signalling to initiate adaptive immune responses. Despite many structure …
Limits on Inferring T-cell Specificity from Partial Information
J Henderson, Y Nagano, M Milighetti… - arXiv preprint arXiv …, 2024 - arxiv.org
A key challenge in molecular biology is to decipher the mapping of protein sequence to
function. To perform this mapping requires the identification of sequence features most …
function. To perform this mapping requires the identification of sequence features most …
Cooperative binding of TCR and CD4 to pMHC enhances TCR sensitivity
Antigen recognition of CD4+ T cells by the T cell receptor (TCR) can be greatly enhanced by
the coreceptor CD4–. Yet, understanding of the molecular mechanism is hindered by the …
the coreceptor CD4–. Yet, understanding of the molecular mechanism is hindered by the …