Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …

A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …

African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine
industry and leading to important global economic consequences. The virus causes a highly …

ABSTRACT CD4 effectors generated in vitro can promote survival against a highly
pathogenic influenza virus via an antibody-independent mechanism involving class II …

The T-box transcription factors T-bet and Eomesodermin (Eomes) have been well defined as
key drivers of immune cell development and cytolytic function. While the majority of studies …

CD4 T cells that acquire cytotoxic phenotype and function have been repeatedly identified in
humans, mice, and other species in response to many diverse pathogens. Since CD4 …

For many years, the focus of prophylactic vaccines was to elicit neutralizing antibodies, but it
has become increasingly evident that T cell-mediated immunity plays a central role in …

In mice, two T-box transcription factors, T-box expressed in T cells (T-bet) and
eomesodermin (Eomes), drive the differentiation of CD8 T cell lineages; however, little is …

Cancer immunotherapies are increasingly combined with targeted therapies to improve
therapeutic outcomes. We show that combination of agonistic anti-CD40 with antiangiogenic …

Granzymes are a family of small (∼ 32 kDa) serine proteases with a range of substrate
specificities that are stored in, and released from, the cytoplasmic secretory vesicles …