Although carbon is the central element of organic chemistry, oxygen is the central element of
stereoelectronic control in organic chemistry. Generally, a molecule with a C–O bond has …

The founding in 1965 of what is now called the Cambridge Structural Database (CSD) has
reaped dividends in numerous and diverse areas of chemical research. Each of the million …

With the ever-increasing number of synthesis-on-demand compounds for drug lead
discovery, there is a great need for efficient search technologies. We present the successful …

Small organic molecules are often flexible, ie, they can adopt a variety of low-energy
conformations in solution that exist in equilibrium with each other. Two main search …

Electron deficient, bivalent sulfur atoms have two areas of positive electrostatic potential, a
consequence of the low-lying σ* orbitals of the C–S bond that are available for interaction …

The methyl group is one of the most commonly occurring carbon fragments in small‐
molecule drugs. This simplest alkyl fragment appears in more than 67% of the top‐selling …

Chemists of all fields currently publish about 50 000 crystal structures per year, the vast
majority of which are X‐ray structures. We determined two molecular structures by …

The book New frontiers on organoselenium compounds, by Lenardão, Santi, and Sancineto,
is destined to become an extremely useful and valuable source for students and researchers …

The generation of conformations for small molecules is a problem of continuing interest in
cheminformatics and computational drug discovery. This review will present an overview of …

Stereoelectronic Effects illustrates the utility of stereoelectronic concepts using structure and
reactivity of organic molecules An advanced textbook that provides an up-to-date overview …