Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an
invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They …

The hepatic immune system is constantly exposed to a massive load of harmless dietary and
commensal antigens, to which it must remain tolerant. Immune tolerance in the liver is …

Liver natural killer and natural killer T cells not only play a critical role in anti–viral and anti–
tumor defenses but also contribute to the pathogenesis of chronic liver diseases. Hepatic …

Hepatitis C (HCV) is a major cause of liver disease, in which a third of individuals with
chronic HCV infections may develop liver cirrhosis. In a chronic HCV infection, host immune …

The liver has unique immune regulatory functions that promote the induction of tolerance
rather than responses to antigens encountered locally. These functions are mediated by …

Dietary factors promote obesity and obesity‐related disorders, such as fatty liver disease.
Natural killer T (NKT) cells are components of the innate immune system that regulate …

The critical metabolic functions of the liver often eclipse any perception of its role as an
immune organ. However, the liver as a mediator of systemic and local innate immunity and …

Identification of human CD1d‐restricted T‐cell receptor (TCR)‐invariant natural killer T
(iNKT) cells has been dependent on utilizing combinations of monoclonal antibodies or …

Natural killer T cells (NKT cells) represent a subset of T lymphocytes that express natural
killer (NK) cell surface markers. A subset of NKT cells, termed invariant NKT cells (iNKT) …

The liver protects the host from gut-derived pathogens yet is tolerant of antigenic challenge
from food and commensal sources. Innate responses involving liver macrophages (Kupffer …