The Biology of Neisseria Adhesins

MC Hung, M Christodoulides - Biology, 2013 - mdpi.com
Members of the genus Neisseria include pathogens causing important human diseases
such as meningitis, septicaemia, gonorrhoea and pelvic inflammatory disease syndrome …

Comparison of lipooligosaccharides from human challenge strains of Neisseria gonorrhoeae

CM John, NJ Phillips, AJ Cardenas, AK Criss… - Frontiers in …, 2023 - frontiersin.org
The alarming rise of antibiotic resistance and the emergence of new vaccine technologies
have increased the focus on vaccination to control gonorrhea. Neisseria gonorrhoeae …

Neisseria gonorrhoeae infects the heterogeneous epithelia of the human cervix using distinct mechanisms

Q Yu, LC Wang, S Di Benigno, SD Gray-Owen… - PLoS …, 2019 - journals.plos.org
Sexually transmitted infections are a critical public health issue. However, the mechanisms
underlying sexually transmitted infections in women and the link between the infection …

[HTML][HTML] Pharmacokinetic/pharmacodynamic considerations for new and current therapeutic drugs for uncomplicated gonorrhoea—challenges and opportunities

U Theuretzbacher, L Barbee, K Connolly… - Clinical Microbiology …, 2020 - Elsevier
Background Increasing multidrug resistance rates in Neisseria gonorrhoeae have raised
concerns and an urgent call for new antibiotics for treatment of gonorrhoea. Several …

Drug resistance mechanisms in bacteria causing sexually transmitted diseases and associated with vaginosis

B Shaskolskiy, E Dementieva, A Leinsoo… - Frontiers in …, 2016 - frontiersin.org
Here, we review sexually transmitted diseases (STDs) caused by pathogenic bacteria and
vaginal infections which result from an overgrowth of opportunistic bacterial microflora. First …

Thiostrepton, a resurging drug inhibiting the stringent response to counteract antibiotic-resistance and expression of virulence determinants in Neisseria gonorrhoeae

A Talà, M Calcagnile, SC Resta, A Pennetta… - Frontiers in …, 2023 - frontiersin.org
Due to the increased resistance to all available antibiotics and the lack of vaccines,
Neisseria gonorrhoeae (the gonococcus) poses an urgent threat. Although the mechanisms …

Transcriptome analysis of Neisseria gonorrhoeae during natural infection reveals differential expression of antibiotic resistance determinants between men and …

K Nudel, R McClure, M Moreau, E Briars, AJ Abrams… - Msphere, 2018 - Am Soc Microbiol
Neisseria gonorrhoeae is a bacterial pathogen responsible for the sexually transmitted
infection gonorrhea. Emergence of antimicrobial resistance (AMR) of N. gonorrhoeae …

Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three‐gene locus

A Avilés‐Reyes, JH Miller… - Molecular oral …, 2014 - Wiley Online Library
Cnm, a collagen‐and laminin‐binding protein present in a subset of S treptococcus mutans
strains, mediates binding to extracellular matrices (ECM), intracellular invasion and …

Characterization of an ntrX Mutant of Neisseria gonorrhoeae Reveals a Response Regulator That Controls Expression of Respiratory Enzymes in Oxidase-Positive …

JM Atack, YN Srikhanta, KY Djoko, JP Welch… - Journal of …, 2013 - Am Soc Microbiol
NtrYX is a sensor-histidine kinase/response regulator two-component system that has had
limited characterization in a small number of Alphaproteobacteria. Phylogenetic analysis of …

Neisseria gonorrhoeae infects the human endocervix by activating non-muscle myosin II-mediated epithelial exfoliation

LC Wang, Q Yu, V Edwards, B Lin, J Qiu… - PLoS …, 2017 - journals.plos.org
Colonization and disruption of the epithelium is a major infection mechanism of mucosal
pathogens. The epithelium counteracts infection by exfoliating damaged cells while …