Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Injury-induced sensitization of nociceptors contributes to pain states and the development of
chronic pain. Inhibiting activity-dependent mRNA translation through mechanistic target of …

Long-term hyperglycemia may lead to diabetic microvascular and macrovascular
complications that can affect the peripheral vascular system, particularly in wound healing …

A sedentary lifestyle is associated with overweight/obesity, which involves excessive fat
body accumulation, triggering structural and functional changes in tissues, organs, and body …

Tetrodotoxin-resistant (TTX-r) sodium channels are key players in determining the input-
output properties of peripheral nociceptive neurons. Changes in gating kinetics or in …

Patients with bone cancer pain (BCP) are more prone to aversion. which not only causes
mental distress but also aggravates BCP. However, the mechanism of BCP-related aversion …

Background Pain is one critical hallmark of inflammatory responses. A large number of
studies have demonstrated that stromal cell-derived factor 1 (SDF1, also named as …

Pathological pain is an enormous medical problem that places a significant burden on
patients and can result from an injury that has long since healed or be due to an …

This review commemorates the 10-year anniversary of the discovery of physiological ligands
Augα (Augmentor α; ALKAL2; Fam150b) and Augβ (Augmentor β; ALKAL1; Fam150a) for …