The ever-changing nature of cancer poses the most difficult challenge oncologists face
today. Cancer's remarkable adaptability has inspired many to work toward understanding …

Known as a diverse collection of neoplastic diseases, breast cancer (BC) can be
hyperbolically characterized as a dynamic pseudo-organ, a living organism able to build a …

The biophysical properties of the cytoplasm are major determinants of key cellular
processes and adaptation. Many yeasts produce dormant spores that can withstand extreme …

Background Therapy resistance in cancer is often driven by a subpopulation of cells that are
temporarily arrested in a non-proliferative G0 state, which is difficult to capture and whose …

Therapeutic resistance is one of the main reasons for treatment failure in cancer patients.
The polyaneuploid cancer cell (PACC) state has been shown to promote resistance by …

Over 40 years ago, seminal papers by Armstrong and McGehee and by Levins showed that
temporal fluctuations in resource availability could permit coexistence of two species on a …

Spores of Bacillus subtilis germinate in response to specific germinant molecules that are
recognized by receptors in the spore envelope. Germinants signal to the dormant spore that …

In this didactic paper, we present a theoretical modeling framework, called the G-function,
that integrates both the ecology and evolution of cancer to understand oncogenesis. The G …

Floodplain wetlands are critical to the conservation of aquatic biodiversity and the ecological
integrity of river networks. However, increasing drought severity and frequency caused by …

In nature, the interaction between pathogens and their hosts is only one of a handful of
interaction relationships between species, including parasitism, predation, competition …