Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

The same genetic variant found in different individuals can cause a range of diverse
phenotypes, from no discernible clinical phenotype to severe disease, even among related …

Fossil-fuel combustion by-products are the world's most significant threat to children's health
and future and are major contributors to global inequality and environmental injustice. The …

Background: Approaches to estimating and addressing the risk to children from fossil fuel
combustion have been fragmented, tending to focus either on the toxic air emissions or on …

ABSTRACT Gestational Diabetes Mellitus (GDM) is the most common metabolic condition
during pregnancy and may result in short-and long-term complications for both mother and …

Crosstalk between cellular metabolism and the epigenome regulates epigenetic and
metabolic homeostasis and normal cell behavior. Changes in cancer cell metabolism can …

Abstract In 1965, Sir Austin Bradford Hill published nine “viewpoints” to help determine if
observed epidemiologic associations are causal. Since then, the “Bradford Hill Criteria” …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

For several exposures, it has been proved that chemicals can alter epigenetic marks, and
that the same or similar epigenetic alterations can be found in patients with the disease of …