It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …

Insulin is a therapeutically relevant molecule with use in treating diabetes patients.
Unfortunately, it undergoes a range of untoward and often unpredictable physical …

Green tea polyphenols (GTPs), particularly epigallocatechin-3-gallate, stand out among
natural small molecules screened for their ability to target protein aggregates due to their …

The concept of developing novel anti-amyloid inhibitors in the scientific community has
engrossed remarkable research interests and embraced significant potential to resolve …

Amyloid proteins were recognized as the crucial cause of many senile diseases. In this
study, the inhibitory effects of Sennoside A (SA) and Sennoside C (SC) on amyloid …

Insulin and its homologous are the most utilized protein drugs due to their role in diabetic
patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the …

Aging and lipid metabolism disorders promote the formation and accumulation of amyloid
with β-sheet structure, closely related to cardiovascular disease, senile dementia, type 2 …

Composite gel beads using calcium alginate and different concentrations of pregelatinized
corn starch (PCS) were produced to encapsulate phycocyanin (PC). Rheological properties …

The aggregation of therapeutic proteins is potentially encountered during various steps such
as bioprocessing, formulation, storage, transportation and administration. The aggregation …

Insulin fibril formation decreases the effectiveness of insulin therapy and causes amyloidosis
in diabetes. Studies suggest that phytochemicals are capable of inhibiting fibril formation …