Neuroinflammation and neurodegeneration often result from the aberrant deposition of
aggregated host proteins, including amyloid‐β, α‐synuclein, and prions, that can activate …

Alzheimer's disease (AD) is a neurodegenerative disease, characterized by progressive loss
of memory which is associated with other cognitive deficits. The two protein structures in the …

Neuroinflammation and microglial activation are significant processes in Alzheimer's
disease pathology. Recent genome-wide association studies have highlighted multiple …

Mutations in β-amyloid (Aβ) precursor protein (APP) cause familial Alzheimer's disease (AD)
probably by enhancing Aβ peptides production from APP. An antibody targeting Aβ …

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder, which is
characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular …

Neuroplasticity is not only shaped by learning and memory but is also a mediator of
responses to neuron attrition and injury (compensatory plasticity). As an ongoing process it …

Alzheimer's disease (AD) is the most common form of dementia, characterized by the
formation of extracellular senile plaques and neuronal loss caused by amyloid β (Aβ) …

People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …

The sequence of cellular dysfunctions in preclinical Alzheimer's disease must be understood
if we are to plot new therapeutic routes. Hippocampal neuronal hyperactivity is one of the …

Antibodies targeting Aβ42 are under intense scrutiny because of their therapeutic potential
for Alzheimer's disease. To enable systematic searches, we present an “antibody scanning” …