Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …
[HTML][HTML] The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies
M Jo, S Lee, YM Jeon, S Kim, Y Kwon… - Experimental & molecular …, 2020 - nature.com
Abstract TAR DNA-binding protein 43 (TDP-43) is a highly conserved nuclear RNA/DNA-
binding protein involved in the regulation of RNA processing. The accumulation of TDP-43 …
binding protein involved in the regulation of RNA processing. The accumulation of TDP-43 …
[HTML][HTML] Neurodegenerative disorders and gut-brain interactions
Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …
[HTML][HTML] Passive immunotherapies targeting Aβ and tau in Alzheimer's disease
SS Plotkin, NR Cashman - Neurobiology of Disease, 2020 - Elsevier
Amyloid-β (Aβ) and tau proteins currently represent the two most promising targets to treat
Alzheimer's disease. The most extensively developed method to treat the pathologic forms of …
Alzheimer's disease. The most extensively developed method to treat the pathologic forms of …
TDP-43 pathology: from noxious assembly to therapeutic removal
Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …
[HTML][HTML] Opinion: more mouse models and more translation needed for ALS
EMC Fisher, L Greensmith, A Malaspina… - Molecular …, 2023 - Springer
Amyotrophic lateral sclerosis is a complex disorder most of which is 'sporadic'of unknown
origin but approximately 10% is familial, arising from single mutations in any of more than 30 …
origin but approximately 10% is familial, arising from single mutations in any of more than 30 …
[HTML][HTML] Molecular mechanisms underlying TDP-43 pathology in cellular and animal models of ALS and FTLD
A Wood, Y Gurfinkel, N Polain, W Lamont… - International journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are
neurodegenerative disorders that exist on a disease spectrum due to pathological, clinical …
neurodegenerative disorders that exist on a disease spectrum due to pathological, clinical …
Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders
SARM1, a protein with critical NADase activity, is a central executioner in a conserved
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
programme of axon degeneration. We report seven rare missense or in-frame microdeletion …
[HTML][HTML] Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases
Neurodegenerative diseases are a set of progressive and currently incurable diseases that
are primarily caused by neuron degeneration. Neurodegenerative diseases often lead to …
are primarily caused by neuron degeneration. Neurodegenerative diseases often lead to …
[HTML][HTML] Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases
The potential to treat neurodegenerative diseases (NDs) of the major bioactive compound of
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …
green tea, epigallocatechin-3-gallate (EGCG), is well documented. Numerous findings now …