The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1–3
(GRHL1, GRHL2 and GRHL3), are transcription factors implicated in wound healing …

About 90% of all malignant tumors are of epithelial nature. The epithelial tissue is
characterized by a close interconnection between cells through cell-cell interactions, as well …

Background & Aims Chronic, excessive alcohol consumption leads to alcoholic liver disease
(ALD) characterized by steatosis, inflammation, and eventually cirrhosis. The hepatocyte …

Abstract Epithelial-mesenchymal transition (EMT), a biological process by which polarized
epithelial cells convert into a mesenchymal phenotype, has been implicated to contribute to …

Background Basal-like breast cancer (BLBC) is one of the most aggressive malignant
diseases in women with an increased metastatic behavior and poor prognosis compared to …

Cell differentiation is affected by complex networks of transcription factors that co-ordinate re-
organisation of the chromatin landscape. The hierarchies of these relationships can be …

Modern technologies enable detection and characterization of circulating tumor cells (CTC)
in peripheral blood samples. Thus, CTC have attracted interest as markers for therapeutic …

Abstract Grainyhead-like 2 (GRHL2), one of the three homologs of Drosophila grainyhead,
contributes to epithelial morphogenesis and differentiation. Dysregulation of GRHL2 has …

Previously, we have identified the Grainyhead transcription factor 2 gene (GRHL2) as
notably hypomethylated in high-grade (HG) serous epithelial ovarian tumors, compared with …

In mammals, the grainyhead-like transcription factor (GRHL) family is composed of three
nuclear proteins that are responsible for driving epithelial cell fate: GRHL1, GRHL2, and …