Stem cells can be defined as units of biological organization that are responsible for the
development and the regeneration of organ and tissue systems. They are able to renew their …

Mechanistic exploration has pinpointed nanosized extracellular vesicles, known as
exosomes, as key mediators of the benefits of cell therapy. Exosomes appear to recapitulate …

Cardiovascular diseases are a leading cause of mortality across the globe, and transplant
surgeries are not always successful since it is not always possible to replace most of the …

Myocardial infarction is a leading cause of morbidity and mortality worldwide. Although
medical and surgical treatments can significantly improve patient outcomes, no treatment …

Adult cardiomyocytes are terminally differentiated cells that result in minimal intrinsic
potential for the heart to self-regenerate. The introduction of novel approaches in cardiac …

Heart failure continues to be one of the leading causes of morbidity and mortality worldwide.
Myocardial infarction is the primary causative agent of chronic heart failure resulting in …

The process of developing new and complex stem-cell-based therapeutics is incremental
and requires decades of sustained collaboration among different stakeholders. In this …

Heart disease remains an increasing major public health challenge in the United States and
worldwide. A common end-organ feature in diseased hearts is myocardial fibrosis, which …

A normal adult heart is composed of several different cell types, among which cardiac
mesenchymal stromal cells represent an abundant population. The isolation of these cells …

Tissue regeneration substantially relies on the functionality of tissue-resident endogenous
adult stem cell populations. However, during aging, a progressive decline in organ function …