Fertility sparing treatments in endometrial cancer patients: the potential role of the new molecular classification

AF Cavaliere, F Perelli, S Zaami… - International Journal of …, 2021 - mdpi.com
Endometrial cancer is the most frequent gynecological malignancy, and, although
epidemiologically it mainly affects advanced age women, it can also affect young patients …

Fertility-sparing approach in women affected by stage I and low-grade endometrial carcinoma: an updated overview

G Gullo, A Etrusco, G Cucinella, A Perino… - International Journal of …, 2021 - mdpi.com
Endometrial cancer (EC) is a deleterious condition which strongly affects a woman's quality
of life. Although aggressive interventions should be considered to treat high-grade EC, a …

Metformin plus megestrol acetate compared with megestrol acetate alone as fertility‐sparing treatment in patients with atypical endometrial hyperplasia and well …

BY Yang, Y Gulinazi, Y Du, CC Ning… - … Journal of Obstetrics …, 2020 - Wiley Online Library
Objective To assess the efficacy of metformin in megestrol acetate (MA)‐based fertility‐
sparing treatment for patients with atypical endometrial hyperplasia (AEH) and endometrioid …

Mismatch repair-deficiency specifically predicts recurrence of atypical endometrial hyperplasia and early endometrial carcinoma after conservative treatment: A multi …

A Raffone, U Catena, A Travaglino, V Masciullo… - Gynecologic …, 2021 - Elsevier
Objective Deficient expression of mismatch repair proteins (MMR) has been suggested to be
a predictor of resistance of atypical endometrial hyperplasia (AEH) and early endometrial …

[HTML][HTML] Treatment efficiency of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young women with endometrial …

B Yang, Y Xu, Q Zhu, L Xie, W Shan, C Ning, B Xie… - Gynecologic …, 2019 - Elsevier
Objective This study aimed to evaluate the efficacy of comprehensive hysteroscopic
evaluation and lesion resection combined with progestin therapy in young patients with …

Upgrading Treatment and Molecular Diagnosis in Endometrial Cancer—Driving New Tools for Endometrial Preservation?

M Dellino, M Cerbone, AS Laganà, A Vitagliano… - International Journal of …, 2023 - mdpi.com
One emerging problem for onco-gynecologists is the incidence of premenopausal patients
under 40 years of age diagnosed with stage I Endometrial Cancer (EC) who want to …

Long-term outcomes of progestin plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer patients

A Mitsuhashi, Y Habu, T Kobayashi… - Journal of …, 2019 - synapse.koreamed.org
Objective The present study investigated long-term outcomes of medroxyprogesterone
acetate (MPA) plus metformin therapy in terms of control of atypical endometrial hyperplasia …

Diabetes mellitus and responsiveness of endometrial hyperplasia and early endometrial cancer to conservative treatment

A Raffone, A Travaglino, G Saccone… - Gynecological …, 2019 - Taylor & Francis
Objective: The conservative treatment of endometrial hyperplasia without atypia (HWA),
atypical endometrial hyperplasia (AH/EIN) and early endometrioid carcinoma (EEC) is …

Fertility preservation in women with early-stage gynecologic cancer: optimizing oncologic and reproductive outcomes

JL Floyd, S Campbell, JA Rauh-Hain… - International Journal of …, 2021 - ijgc.bmj.com
Almost all standard therapies for gynecologic cancer, including surgical intervention,
gonadotoxic chemotherapy, and radiation therapy, threaten a woman's childbearing …

A prospective cohort study of metformin as an adjuvant therapy for infertile women with endometrial complex hyperplasia/complex atypical hyperplasia and their …

W Kong, Z Liu, N Zhang, X Wu, X Zhao… - Frontiers in …, 2022 - frontiersin.org
Objective To investigate the adjuvant efficacy of metformin treatment to achieve pathological
complete response (CR) in patients with endometrial complex hyperplasia (CH) and …