Ferroptosis is a regulated form of cell death induced by iron (Fe)-dependent lipid
peroxidation. At present, the underlying molecular mechanisms remain elusive. Herein, we …

Copper (Cu) is a vital trace element for maintaining human health. Current evidence
suggests that genes responsible for regulating copper influx and detoxification help …

Ferroptosis, a regulated form of cell death, is characterized by iron-dependent lipid
peroxidation leading to oxidative damage to cell membranes. Cell sensitivity to ferroptosis is …

Due to many special characteristics, zinc oxide nanoparticles (ZnO NPs) are widely used all
over the world, leading to their wide distribution in the environment. However, the toxicities …

Exposure to excessive manganese (Mn) is toxic to humans and animals. However, the toxic
effects and mechanisms of excessive Mn influencing the vertebrates have been highly …

Iron is an essential micro-element, involved in multiple biological activities in vertebrates.
Excess iron accumulation has been identified as an important mediator of lipid deposition …

High concentrations of copper (Cu2+) pose a great threat to aquatic animals. However, the
mechanisms underlying the response of crustaceans to Cu2+ exposure have not been well …

Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor
prognosis and low 5-year survival rate less than 10%. Although surgical resection and …

Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver
disease worldwide. Minerals including iron, copper, zinc, and selenium, fulfil an essential …

Copper (Cu) is an essential and important trace element for some significant life processes
for most organisms. However, an excessive amount of Cu can be highly toxic. The present …