Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

Type 1 and type 2 diabetes are characterized by chronic inflammation; both diseases
involve pancreatic islet inflammation, while systemic low-grade inflammation is a feature of …

Chronic, unresolved tissue inflammation is a well-described feature of obesity, type 2
diabetes mellitus (T2DM) and other insulin-resistant states. In this context, adipose tissue …

Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

We report a method of cancer immunotherapy using an attenuated Salmonella typhimurium
strain engineered to secrete Vibrio vulnificus flagellin B (FlaB) in tumor tissues. Engineered …

Inhibitory Smads (I-Smads) have conserved carboxy-terminal MH2 domains but highly
divergent amino-terminal regions when compared with receptor-regulated Smads (R …

The nature of obesity-associated islet inflammation and its impact on β cell abnormalities
remains poorly defined. Here, we explore immune cell components of islet inflammation and …

The finding of islet inflammation in type 2 diabetes (T2D) and its involvement in β cell
dysfunction has further highlighted the significance of inflammation in metabolic diseases …

Heterotopic ossification (HO) is the formation of extraskeletal bone in non-osseous tissues. It
is caused by an injury that stimulates abnormal tissue healing and regeneration, and …