A field guide to flow chemistry for synthetic organic chemists

L Capaldo, Z Wen, T Noël - Chemical science, 2023 - pubs.rsc.org
Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea
that it is a mysterious “black box” needs to go. In this review, we show that several of the …

Efficient C(sp3)−H Carbonylation of Light and Heavy Hydrocarbons with Carbon Monoxide via Hydrogen Atom Transfer Photocatalysis in Flow**

F Raymenants, TM Masson… - Angewandte Chemie …, 2023 - Wiley Online Library
Despite their abundance in organic molecules, considerable limitations still exist in synthetic
methods that target the direct C− H functionalization at sp3‐hybridized carbon atoms. This is …

Combining computational fluid dynamics, photon fate simulation and machine learning to optimize continuous-flow photocatalytic systems

GX de Oliveira, S Kuhn, HG Riella, C Soares… - Reaction Chemistry & …, 2023 - pubs.rsc.org
Photoredox catalysis is a well-established area with great potential for industrial
applications. The need for an optimum process with less waste generation and economic …

Controlling the crystallisation and hydration state of crystalline porous organic salts

M O'Shaughnessy, AC Padgham… - … A European Journal, 2023 - Wiley Online Library
Crystalline porous organic salts (CPOS) are a subclass of molecular crystals. The low
solubility of CPOS and their building blocks limits the choice of crystallisation solvents to …

Modular Photochemical Flow Synthesis of Structurally Diverse Benzyne and Triazine Precursors

J García‐Lacuna, M Baumann - Advanced Synthesis & …, 2023 - Wiley Online Library
Benzyne and related arynes are classical high‐energy species with a rich history of
widespread applications in synthesis. However, despite several synthetic routes being …

Continuous Flow Oxidation of Alcohols Using TEMPO/NaOCl for the Selective and Scalable Synthesis of Aldehydes

P Naik, J García-Lacuna, P O'Neill… - … Process Research & …, 2023 - ACS Publications
A simple and benign continuous flow oxidation protocol for the selective conversion of
primary and secondary alcohols into their respective aldehyde and ketone products is …

Modular Synthesis of Benzoylpyridines Exploiting a Reductive Arylation Strategy

AI Alfano, M Smyth, S Wharry, TS Moody… - Organic …, 2023 - ACS Publications
Herein we disclose a telescoped flow strategy to access electronically differentiated bisaryl
ketones as potentially new and tunable photosensitizers containing both electron-rich …

Enabling high throughput kinetic experimentation by using flow as a differential kinetic technique

G Lennon, P Dingwall - Angewandte Chemie International …, 2024 - Wiley Online Library
Kinetic data is most commonly collected through the generation of time‐series data under
either batch or flow conditions. Existing methods to generate kinetic data in flow collect …

Fully Automated Flow Protocol for C(sp3)–C(sp3) Bond Formation from Tertiary Amides and Alkyl Halides

B Pijper, R Martín, AJ Huertas-Alonso, ML Linares… - Organic …, 2023 - ACS Publications
Herein, we present a novel C (sp3)–C (sp3) bond-forming protocol via the reductive
coupling of abundant tertiary amides with organozinc reagents prepared in situ from their …

A three-minute gram-scale synthesis of amines via ultrafast “on-water” in continuo organolithium addition to imines

J Brucoli, A Puglisi, S Rossi, D Gariboldi… - Cell Reports Physical …, 2024 - cell.com
Although" on-water" organic reactions, including organometallics, are a sustainable
alternative to traditional strategies, serious concerns related to the safety and feasibility of …