The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

Left ventricular (LV) hypertrophy (LVH) is a growth in left myocardial mass mainly caused by
increased cardiomyocyte size. LVH can be a physiological adaptation to physical exercise …

Recently, a new paradigm for the development of heart failure with preserved ejection
fraction (HFpEF) has been proposed, which identifies a systemic pro-inflammatory state …

The vascular endothelium is a multifunctional cellular system which directly influences blood
components and cells within the vessel wall in a given tissue. Importantly, this cellular …

The pathogenesis of many cardiovascular diseases is associated with reduced nitric oxide
(NO) bioavailability and/or increased endothelial NO synthase (eNOS)-dependent …

Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of
animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular …

Heart failure with preserved ejection fraction (HFpEF) is a complex, heterogeneous disease
characterized by autonomic imbalance, cardiac remodeling, and diastolic dysfunction. One …

Nitric oxide (NO) formed via endothelial NO synthase (eNOS) and neuronal NO synthase
(nNOS) plays crucial roles in the regulation of blood flow through vasodilatation and …

Background and Purpose—Poststroke hyperglycemia and diabetes mellitus are associated
with lower thrombolytic efficacy and an increased risk of postischemic cerebral hemorrhage …

Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the
treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been …