Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat
stimulates transcription elongation by directing the cellular transcriptional elongation factor P …

More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …

▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

Most of the human genome is transcribed into protein-noncoding RNAs (ncRNAs), including
small ncRNAs and long ncRNAs (lncRNAs). Over the past decade, rapidly emerging …

Background: The expression of both the env and gag gene products of human
immunodeficiency virus type 1 (HIV-1) is known to be limited by cis elements in the viral …

ABSTRACT DNA vaccination elicits humoral and cellular immune responses and has been
shown to confer protection against several viral, bacterial, and parasitic pathogens. Here we …

Autologous expression of recombinant human proteins in human cells for biomedical
research and product development is often hampered by low expression yields limiting …

We have characterized an inhibitory RNA element in the human immunodeficiency virus
type 1 (HIV-1) gag coding sequence that prevents gag expression. The inhibition exerted by …

The human immunodeficiency virus (HIV) genome is AU rich, and this imparts a codon bias
that is quite different from the one used by human genes. The codon usage is particularly …

Expression of human immunodeficiency virus type 1 (HIV-1) structural proteins requires the
presence of the viral trans-activator protein Rev. Rev is localized in the nucleus and binds …