Switchable and dynamic G-quadruplexes and their applications
G-Quadruplexes attract growing interest as functional constituents in biology, chemistry,
nanotechnology, and material science. In particular, the reversible dynamic reconfiguration …
nanotechnology, and material science. In particular, the reversible dynamic reconfiguration …
[HTML][HTML] Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …
rich sequences, and has profound implications for various pharmacological and biological …
Detection of genomic G-quadruplexes in living cells using a small artificial protein
K Zheng, J Zhang, Y He, J Gong, C Wen… - Nucleic acids …, 2020 - academic.oup.com
Abstract G-quadruplex (G4) structures formed by guanine-rich nucleic acids are implicated
in essential physiological and pathological processes and serve as important drug targets …
in essential physiological and pathological processes and serve as important drug targets …
[HTML][HTML] Multimeric G-quadruplexes: A review on their biological roles and targeting
In human cells, nucleic acids adopt several non-canonical structures that regulate key
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …
Ligand design to acquire specificity to intended G‐quadruplex structures
S Asamitsu, T Bando… - Chemistry–A European …, 2019 - Wiley Online Library
AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …
sequences, and is considered to be relevant in various pharmacological and biological …
Development of near-infrared nucleic acid mimics of fluorescent proteins for in vivo imaging of viral RNA with turn-on fluorescence
J Zhang, H Li, B Lin, X Luo, P Yin, T Yi… - Journal of the …, 2021 - ACS Publications
GFP-like fluorescent proteins and their molecular mimics have revolutionized bioimaging
research, but their emissions are largely limited in the visible to far-red region, hampering …
research, but their emissions are largely limited in the visible to far-red region, hampering …
Transient Out‐of‐Equilibrium Nucleic Acid‐Based Dissipative Networks and Their Applications
Z Li, J Wang, I Willner - Advanced Functional Materials, 2022 - Wiley Online Library
Dynamic, dissipative reactions play important roles in biological processes, and emulating
such biological processes by artificial circuits and networks is a challenging topic in the area …
such biological processes by artificial circuits and networks is a challenging topic in the area …
[HTML][HTML] How to untie G-quadruplex knots and why?
P Lejault, J Mitteaux, FR Sperti, D Monchaud - Cell chemical biology, 2021 - cell.com
For over two decades, the prime objective of the chemical biology community studying G-
quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to …
quadruplexes (G4s) has been to use chemicals to interact with and stabilize G4s in cells to …
Mechanistic insights into the ligand-induced unfolding of an RNA G-quadruplex
S Haldar, Y Zhang, Y Xia, B Islam, S Liu… - Journal of the …, 2022 - ACS Publications
The cationic porphyrin TMPyP4 is a well-established DNA G-quadruplex (G4) binding ligand
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …
that can stabilize different topologies via multiple binding modes. However, TMPyP4 can …
Stability prediction of canonical and non-canonical structures of nucleic acids in various molecular environments and cells
S Takahashi, N Sugimoto - Chemical Society Reviews, 2020 - pubs.rsc.org
Nucleic acids (DNA and RNA) dynamically fold and unfold to exert their functions in cells.
These folding and unfolding behaviours are also the basis for various technical applications …
These folding and unfolding behaviours are also the basis for various technical applications …