EMT and MET comprise the processes by which cells transit between epithelial and
mesenchymal states, and they play integral roles in both normal development and cancer …

DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years. Alterations in …

Motivation: DNA methylation is an epigenetic mechanism of gene regulation. Bisulfite-
conversion-based PCR methods, such as bisulfite sequencing PCR (BSP) and methylation …

Recent studies have shown that small noncoding RNAs, such as microRNAs and siRNAs,
regulate gene expression at multiple levels including chromatin architecture, transcription …

Prostate cancer is a main urological disease associated with significant morbidity and
mortality. Radical prostatectomy and radiotherapy are potentially curative for localized …

This review focuses on new findings and controversial issues in the pathology and
molecular biology of adenocarcinoma of the prostate. Since management of high-grade …

Cadmium is a human carcinogen that likely acts via epigenetic mechanisms. Since DNA
methylation alterations represent an important epigenetic event linked to cancer, the effect of …

Objective To provide an introduction to the concept of DNA methylation and its function in
normal cells, and to explain the possible mechanisms as to how abnormalities in this …

The most commonly diagnosed breast cancer (BC) subtype is characterized by estrogen
receptor (ER) expression. Treatment of this BC subtype typically involves modalities that …

Estrogens have significant direct and indirect effects on prostate gland development and
homeostasis and have been long suspected in playing a role in the etiology of prostatic …