Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

Immune checkpoint inhibitors (ICIs) targeting PD-1 or PD-L1 have emerged as a
revolutionary treatment strategy for human cancer patients. However, as the response rate to …

Tumour immunotherapy has achieved remarkable clinical success in many different types of
cancer in the past two decades. The outcome of immune checkpoint inhibitors in cancer …

Primary colorectal cancer (CRC) often leads to liver metastasis, possibly due to the
formation of pre-metastatic niche (PMN) in liver. Thus, unravelling the key modulator in …

Background Although immunotherapy is effective in improving the clinical outcomes of
patients with bladder cancer (BC), it is only effective in a small percentage of patients …

Non-coding RNAs (ncRNAs) are a group of molecules critical for cell development and
growth regulation. They are key regulators of important cellular pathways in the tumor …

Simple Summary Consensus Molecular Subtypes have recently been proposed based on
molecular and immune landscape of colorectal carcinoma (CRC). Only mismatch repair …

Spatial omics technologies can help identify spatially organized biological processes, but
existing computational approaches often overlook structural dependencies in the data. Here …

Background: Colorectal carcinogenesis and progression are related to the gut microbiota
and the tumor immune microenvironment. Our previous clinical trial demonstrated that …

Intervertebral disc degeneration (IVDD) is one of the most prevalent causes of chronic low
back pain. The role of m6A methylation modification in disc degeneration (IVDD) remains …