B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V
(D) J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR) …

Genome-wide association studies (GWASs) have identified thousands of loci associated
with hundreds of complex diseases and traits, and progress is being made toward …

Whole genome bisulphite sequencing (WGBS) permits the genome-wide study of single
molecule methylation patterns. One of the key goals of mammalian cell-type identity studies …

Variants within non-coding genomic regions can greatly affect disease. In recent years,
increasing focus has been given to these variants, and how they can alter regulatory …

Abstract The Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) is
a fundamental epigenomics approach and has been widely used in profiling the chromatin …

Background As missing values are frequently present in genomic data, practical methods to
handle missing data are necessary for downstream analyses that require complete data …

Background Changes in cell-type composition of tissues are associated with a wide range of
diseases and environmental risk factors and may be causally implicated in disease …

Eating disorders are complex heritable conditions influenced by both genetic and
environmental factors. Given the progress of genomic discovery in anorexia nervosa, with …

Genetic instability is a major concern for successful application of stem cells in regenerative
medicine. However, the mutational consequences of the most applied stem cell therapy in …

Most studies aiming to identify epigenetic biomarkers do so from complex tissues that are
composed of many different cell-types. By definition, these cell-types vary substantially in …