[HTML][HTML] Integrative analysis of 3604 GWAS reveals multiple novel cell type-specific regulatory associations
CE Breeze, E Haugen, A Reynolds, A Teschendorff… - Genome biology, 2022 - Springer
Background Genome-wide association study (GWAS) single nucleotide polymorphisms
(SNPs) are known to preferentially co-locate to active regulatory elements in tissues and cell …
(SNPs) are known to preferentially co-locate to active regulatory elements in tissues and cell …
Epigenetic and transcriptional variability shape phenotypic plasticity
Epigenetic and transcriptional variability contribute to the vast diversity of cellular and
organismal phenotypes and are key in human health and disease. In this review, we …
organismal phenotypes and are key in human health and disease. In this review, we …
[HTML][HTML] Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive
pulmonary disease (COPD) are far from being understood. Here, we determine disease …
pulmonary disease (COPD) are far from being understood. Here, we determine disease …
The NIEHS TaRGET II Consortium and environmental epigenomics
To the Editor: We describe here the aims and scope of one component of the US National
Institute of Environmental Health Sciences'(NIEHS) multiphased Toxicant Exposures and …
Institute of Environmental Health Sciences'(NIEHS) multiphased Toxicant Exposures and …
[PDF][PDF] Comprehensive analysis of chromatin states in atypical teratoid/rhabdoid tumor identifies diverging roles for SWI/SNF and polycomb in gene regulation
Biallelic inactivation of SMARCB1, encoding a member of the SWI/SNF chromatin
remodeling complex, is the hallmark genetic aberration of atypical teratoid rhabdoid tumors …
remodeling complex, is the hallmark genetic aberration of atypical teratoid rhabdoid tumors …
The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome
We report a systematic analysis of the DNA methylation variability in 1,595 samples of
normal cell subpopulations and 14 tumor subtypes spanning the entire human B-cell …
normal cell subpopulations and 14 tumor subtypes spanning the entire human B-cell …
[PDF][PDF] Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers
O Dufva, S Gandolfi, J Huuhtanen, O Dashevsky… - Immunity, 2023 - cell.com
Cancer cells can evade natural killer (NK) cell activity, thereby limiting anti-tumor immunity.
To reveal genetic determinants of susceptibility to NK cell activity, we examined interacting …
To reveal genetic determinants of susceptibility to NK cell activity, we examined interacting …
[HTML][HTML] scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cells
Single-cell DNA methylation profiling currently suffers from excessive noise and/or limited
cellular throughput. We developed scTAM-seq, a targeted bisulfite-free method for profiling …
cellular throughput. We developed scTAM-seq, a targeted bisulfite-free method for profiling …
Fine-mapping genetic associations
Whilst thousands of genetic variants have been associated with human traits, identifying the
subset of those variants that are causal requires a further 'fine-mapping'step. We review the …
subset of those variants that are causal requires a further 'fine-mapping'step. We review the …
Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome
I Shchukina, J Bagaitkar, O Shpynov, E Loginicheva… - Nature aging, 2021 - nature.com
The impact of healthy aging on molecular programming of immune cells is poorly
understood. Here we report comprehensive characterization of healthy aging in human …
understood. Here we report comprehensive characterization of healthy aging in human …